Detection of Colorectal Cancer by Faecal α1-Antitrypsin

α1-ANTITRYPSIN-OLD DOG NEW TRICKS: α1-ANTITRYPSIN EXERTS IN VITRO ANTI-INFLAMMATORY ACTIVITY IN HUMAN MONOCYTES BY ELEVATING cAMP

extremal region detection guided by maxima of gradient magnitude

a problem of computer vision applications is to detect regions of interest under dif- ferent imaging conditions. the state-of-the-art maximally stable extremal regions (mser) detects affine covariant regions by applying all possible thresholds on the input image, and through three main steps including: 1) making a component tree of extremal regions’ evolution (enumeration), 2) obtaining region ...

Molecular Mechanism of Z α1-Antitrypsin Deficiency*

The Z mutation (E342K) of α1-antitrypsin (α1-AT), carried by 4% of Northern Europeans, predisposes to early onset of emphysema due to decreased functional α1-AT in the lung and to liver cirrhosis due to accumulation of polymers in hepatocytes. However, it remains unclear why the Z mutation causes intracellular polymerization of nascent Z α1-AT and why 15% of the expressed Z α1-AT is secreted in...

Cloning of truncation variants of α1-antitrypsin

Introduction Alpha1-antitrypsin is a member of the serpin (serine protease inhibitor) family of proteins . It controls the breakdown of elastic tissue in the lung by inhibiting human neutrophil elastase. It does so by the remarkable serpin mechanism forming a covalent complex with the enzyme and undergoing a dramatic, stabilising conformational change in order to fully disable it . However this...

Detection of Microsatellite Instability by High-Resolution Melting Analysis in Colorectal Cancer

Background: Colorectal cancer (CRC) is the third most common cancer worldwide. microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair system and happens in almost 15% of CRCs. Because of a wide frequency of MSI+ CRC in Iran compared to other parts of the world, the importance of screening for this type of cancer is highlighted. Methods: The most common MSI detecti...